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Purguratives
Prucalopride
Prucalopride
Prucalopride
*Prucalopride*
#Formulations : Tablet
#Pharmacological_Action : It activates prejunctional 5- HT⁴ receptors on intrinsic enteric neurones to enhance release of acetylcholine thereby promoting propulsive contraction in ileum and more prominent in colon.
#Dose : 2mg OD
#Therapeutic_Uses : used as purguratives.
Lubiprostone
Prucalopride
Prucalopride
*Lubiprostone*
#Formulations : Capsule
#Brand_Names : Lubowel
#Pharmacological_Action : It is an EP⁴ receptor agonist which activates mucosal Cl- channels by stimulating guanyl- cyclase C. It produces Cl- rich intestinal fluid and accelerate colonic transit.
#Dose : 24 ug BD
#Therapeutic_Uses : used as purguratives.
Lactulose
Prucalopride
Lactulose
*Lactulose*
#Formulations : Liquid, Suspension
#Brand_Names : Lacsan, Mtlac, Duphalac, Livo- Luk, Looz
#Pharmacological_Action : It is a semisynthetic disaccharide of fructose and lactose which is neither digested nor absorbed in the small intestine therefore retains water. It is broken down in colon by bacteria to osmotically more active an
*Lactulose*
#Formulations : Liquid, Suspension
#Brand_Names : Lacsan, Mtlac, Duphalac, Livo- Luk, Looz
#Pharmacological_Action : It is a semisynthetic disaccharide of fructose and lactose which is neither digested nor absorbed in the small intestine therefore retains water. It is broken down in colon by bacteria to osmotically more active and weakly acidic products.
#Therapeutic_Uses : used as purguratives.
Lactitol
Bisacodyl
Lactulose
*Lactitol*
#Formulations : Syrup, Granules , Sachet
#Brand_Names : Lactihep, Gutclear, Eva Q, Lactitol, Cadilose
#Pharmacological_Action : same as lactulose
#Therapeutic_Uses : used as purguratives.
Bisacodyl
Bisacodyl
Bisacodyl
*Bisacodyl*
#Formulations : Tablet, Suppository
#Brand_Names : Dulcolax, Conlax
#Pharmacological_Action : It is absorbed in the intestine and excreted in bile to undergo partial enterohepatic circulation. After activation in the intestine by deacetylation it irritates colonic mucosa to increase fluid secretion as well as stimulate enteric ne
*Bisacodyl*
#Formulations : Tablet, Suppository
#Brand_Names : Dulcolax, Conlax
#Pharmacological_Action : It is absorbed in the intestine and excreted in bile to undergo partial enterohepatic circulation. After activation in the intestine by deacetylation it irritates colonic mucosa to increase fluid secretion as well as stimulate enteric neurones to enhance peristaltic movement.
#Dose : 5-10 mg
#Therapeutic_Uses : used as purguratives.
Ducosates
Bisacodyl
Bisacodyl
*Ducosates*
#Formulations : Capsule, Tablet, Suspension
#Brand_Names : Cellubril, Laxicon, Doslax
#Pharmacological_Action : It softens the stool by net water accumulation in the lumen by an action on the intestinal mucosa. It emulsifies the colonic contents and increases penetrations of water into the faeces. By using detergent action, it ca
*Ducosates*
#Formulations : Capsule, Tablet, Suspension
#Brand_Names : Cellubril, Laxicon, Doslax
#Pharmacological_Action : It softens the stool by net water accumulation in the lumen by an action on the intestinal mucosa. It emulsifies the colonic contents and increases penetrations of water into the faeces. By using detergent action, it can disrupt the mucosal barrier and enhance absorption of many nonadsorbable drugs.
#Dose : 100- 400 mg/day
#Therapeutic_Uses : used as purguratives.