#Pharmacological_Action : It inhibits arabinosyl transferases involved in arabinogalactan synthesis thereby interfering with mycolic acid incorporation in mycobacteria cell wall.
#Pharmacological_Action : It inhibits synthesis of folate synthase of mycobacterium tuberculosis.
#Dose : 10- 12 g/day
#Therapeutic_Uses : used as antitubercular Drugs.
Pyrazinamide
Pyrazinamide
Para Amino Salicylic Acid
*Pyrazinamide*
#Formulations : Tablet, Syrup
#Brand_Names : Pyzina, Pza-Ciba , Rizap
#Pharmacological_Action : It is same as isoniazid. It is more lethal to intracellularly located bacilli and to those at sites showing an inflammatory response, probably because pH is acidic at both these locations.
#Side_Effects : Hyperuricaemia, Gout, Rashe
*Pyrazinamide*
#Formulations : Tablet, Syrup
#Brand_Names : Pyzina, Pza-Ciba , Rizap
#Pharmacological_Action : It is same as isoniazid. It is more lethal to intracellularly located bacilli and to those at sites showing an inflammatory response, probably because pH is acidic at both these locations.
#Pharmacological_Action : It interrupts RNA synthesis by binding to ß subunit of mycobacterial DNA dependent RNA polymerase and blocking it's polymerizing function. The basis of selective toxicity is that mammalian RNA polymerase doesn't avidly bind rifampin.
#Pharmacological_Action : It interrupts RNA synthesis by binding to ß subunit of mycobacterial DNA dependent RNA polymerase and blocking it's polymerizing function. The basis of selective toxicity is that mammalian RNA polymerase doesn't avidly bind rifampin.
#Side_Effects : Rashes, Redness, Chills, Fever, Headache, Malaise, Bone Pain
#Dose : 10 mg/kg
#Therapeutic_Uses : used as antitubercular Drugs.
Bedaquilline
Pyrazinamide
Bedaquilline
*Bedaquiline*
#Formulations : Tablet
#Brand_Names : Sirturo
#Pharmacological_Action : It inhibits mycobacterial ATP synthase, thereby limiting energy production within mycobacterial cell. It has exhibited strong bactericidal and sterilizing activity against Mycobacterium tuberculosis in in vitro tests and in animal models by killing both rap
*Bedaquiline*
#Formulations : Tablet
#Brand_Names : Sirturo
#Pharmacological_Action : It inhibits mycobacterial ATP synthase, thereby limiting energy production within mycobacterial cell. It has exhibited strong bactericidal and sterilizing activity against Mycobacterium tuberculosis in in vitro tests and in animal models by killing both rapidly multiplying as well as dormant bacilli.