Antihistamines

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*Loratadine*


#Formulations : Tablet, Suspension

#Brand_Names : Lorfast, Loridin, Lormeg


#Pharmacological_Action : Long acting CNS lifter drug partly metabolised by CYP3A4 to an active metabolite with a longer t½ of 17 hr.

#Dose : 5mg oral

#Therapeutic_Uses : used as antihistamines.

*Desloratadine*

#Formulations : Tablet

#Brand_Names : Deslor, Lorday, Neoloridin

#Pharmacological_Action : It is the major active metabolite of loratadine effective at half the dose. Noninterference with psychomotor performance and cardiac safety are documented.


#Therapeutic_Uses : used as antihistamines.

*Levocetrizine*

#Formulations : Tablet, Syrup

#Brand_Names : Levosiz, Levorid, Teczine

#Pharmacological_Action : It is the active R (-) enantiomer of cetrizine.

#Dose : 5-10 mg oral

#Therapeutic_Uses : used as antihistamines.

*Mizolastine*

#Formulations : Tablet

#Brand_Names : Elina

#Introduction : This non sedating antihistaminic is effective in allergic rhinitis and Urticaria. 

#Dose : 10mg oral

#Therapeutic_Uses : used as antihistamines

*Ebastine*

#Formulations : Tablet

#Brand_Names : Ebast

#Pharmacological_Action : It rapidly converts into the active metabolite carbastine having a t½ of 10- 16 hr. Non sedating and active in nasal and skin allergy. 

#Dose : 10 mg oral

#Therapeutic_Uses : used as antihistamines.

*Rupatadine*

#Formulations : Tablet 

#Brand_Names : Rupahist

#Introduction : Recently introduced antihistaminic has additional platelet activating factor antagonist property, and is indicated in allergic rhinitis. 

#Dose : 10 mg oral

#Therapeutic_Uses : used as antihistamines