Antiarrhythmic Drugs

Quinidine

Procainamide

*Quinidine*

#Formulations : Tablet

#Brand_Names : Phenipam, Natcardine, Cardioquin, Quinaglute, Quinalan

#Dose : 100 to 200 mg TDS.

#Pharmacological_Action : It blocks sodium channel. It has cardiac antivagal action which augments prolongation of atrial ERP and minimizes RP disparity of atrial fibres. A-V node ERP is increased by direct acti

*Quinidine*

#Formulations : Tablet

#Brand_Names : Phenipam, Natcardine, Cardioquin, Quinaglute, Quinalan

#Dose : 100 to 200 mg TDS.

#Therapeutic_Uses : used as antiarrhythmic Drugs.

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Procainamide

*Procainamide*

#Formulations : Tablet, Injection

#Brand_Names : Pronestyl

#Pharmacological_Action : It is orally active amide derivative of the local anaesthetic procaine with cardiac electrophysiological actions almost identical to those of quinidine. It also blocks Na+ channel.

#Side_Effects : Nausea, Vomiting

#Dose : 0.5-1g

#Therapeutic_Uses : used as antiarrhythmic Drugs.

Lidocaine

Procainamide

Amiodarone

*Lidocaine*

#Formulations : Injection

#Brand_Names : Xylocard, Gesicard

#Pharmacological_Action : It also blocks Na+ channel more in the inactivated than in the open state, but do not delay channel recovery. It do not delay A-V conduction or prolong APD, ERP and Q-T.

#Side_Effects : Drowsiness, Nausea, Paresthesias, Blurred Vision

#Dose : 50-

*Lidocaine*

#Formulations : Injection

#Brand_Names : Xylocard, Gesicard

#Pharmacological_Action : It also blocks Na+ channel more in the inactivated than in the open state, but do not delay channel recovery. It do not delay A-V conduction or prolong APD, ERP and Q-T.

#Side_Effects : Drowsiness, Nausea, Paresthesias, Blurred Vision

#Dose : 50- 100 mg

#Therapeutic_Uses : used as antiarrhythmic Drugs.

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Amiodarone

*Amiodarone*

#Formulations : Tablet, Injection

#Brand_Names : Cordarone, Aldarone, Eurythmic

#Pharmacological_Action : It prolongs repolarization; Active Potential is widened and Electrode Rest Potential is increased. The tissue remains refractory even after full repolarization: reentrant arrhythmias are terminated.

#Side_Effects : Nausea, V

*Amiodarone*

#Formulations : Tablet, Injection

#Brand_Names : Cordarone, Aldarone, Eurythmic

#Side_Effects : Nausea, Vomitting

#Dose : 400-600 mg /day

#Therapeutic_Uses : used as antiarrhythmic Drugs

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Sotalol

Amiodarone

Verapamil

*Sotalol*

#Formulations : Tablet

#Brand_Names : Sotalar, Sotagard

#Pharmacological_Action : same as amiodarone.

#Therapeutic_Uses : used as antiarrhythmic Drugs.

Verapamil

Amiodarone

Verapamil

*Verapamil*

#Formulations : Tablet, Injection

#Brand_Names : Calaptin

#Pharmacological_Action : It blocks L type Ca++ channels and delays their recovery. It supress automaticity and reentry dependent on slow channel response which is more likely in partially depolarized fibres.

#Therapeutic_Uses : used as antiarrhythmic Drugs.